Bio-protective membrane (liquid multifunctional hemostatic material) overview
First, the product name
       Bio-protective film

Second, the main ingredients
       Sodium carboxymethyl cellulose, biopolysaccharides, etc.

Third, the introduction
       This product has a good hemostasis effect on bleeding during surgery, which is degraded to monosaccharide, and the products are CO2 and H2O. At the same time, this product is made of natural plant fiber through biotechnology and controlled oxidation. There is no rejection reaction of animal extract products, and there is no aseptic inflammatory reaction of chemical synthetic products. This product is a suitable substitute for traditional hemostatic materials. Traditional hemostatic materials are generally solid. For some irregular wound hemorrhages, traditional solid hemostatic materials have a hemostatic blind zone and cannot fully contact all bleeding sites. The bio-protective membrane is liquid, which can fully contact and stop bleeding to every part. At the same time, the traditional solid hemostatic material has a single function, and the bio-protective membrane not only stops bleeding, but also has long-acting antibacterial, wound washing, anti-adhesion, and promoting healing functions, effectively reducing the work intensity of medical staff and effectively reducing patient expenses.

Fourth, the applicable department
       Open surgery, laparoscopic surgery, thoracoscopic surgery, orthopedic surgery, emergency surgery, burn and plastic surgery.

Fifth, the main role
       Wound hemostasis, wound washing, long-lasting antibacterial, anti-tissue adhesion, and promote healing.

Sixth, usage and dosage
       Traditional open surgery (including emergency surgery, orthopedics), direct flushing. Generally use 50ml-250ml at a time or adjust the dosage according to the actual situation of the operation.
       Minimally invasive surgery (thoracoscopy, laparoscopy, etc.) can be done with a disposable irrigation line or other flushing material to wash with this product. The general dosage is 100ml or it can be decided by the doctor according to the actual situation.
       Surgical equipment that requires a large amount of flushing fluid (such as pulse flushing) may use other disposable containers to put multiple bags of the product together for subsequent washing.
       Burn plastic surgery can be directly washed with this product or infiltrated with sterile dressing for covering, rubbing and wet application. The dosage is determined by the actual situation.

seventh, special tips
       After using this product to stop bleeding and flushing function, as with other washing products, the residual liquid should be sucked out.

Eighth, hemostasis
       The main component of the bio-protective film is sodium carboxymethylcellulose, a local hemostatic material obtained by fiber treatment. Has good tissue compatibility and no rejection.

Ninth, the mechanism of hemostasis of sodium carboxymethyl cellulose
       1. The acidic carboxyl group binds to Fe2+ in hemoglobin to form a brown viscous gel block, which blocks the end of the capillary and stops bleeding.
       2. In addition, it also has adhesion and aggregation to platelets, which can accelerate coagulation.
       Carboxymethylcellulose sodium has been approved by many years of clinical trials (for example, a foreign hemostatic gauze), and the oozing effect on surgical wounds is good. Hemostasis is usually completed in 2-8 minutes.

Tenth, observation of hemostasis effect of bio-protective membrane
       1, method:
       Twenty-four healthy adult ICR mice, weighing 20±2g, male and female, were randomly divided into two groups; experimental group; control group
       After 10% urethane was intraperitoneally injected with 1g/kg for anesthesia, the tail of the mouse was cut 1cm. When bleeding, the test group used a non-fat gauze with a bio-protective film, and the control group used a small piece of sterile gauze.
       At the same time, the timing was started, and the blood of the wound was sucked out by the filter paper in 10 seconds until the bleeding stopped.
       The bleeding time was recorded, the data was statistically processed, and the significance test was performed between the groups.
       The bleeding time of the test group was 1.5±1.5 (min), the disinfection gauze group was 4.85±1.4, the difference between the two groups was significant (P<0.01); the bleeding time of the test group was shortened by 70%.
       2. Conclusion: Bio-protective membrane has obvious hemostasis

Eleventh, antibacterial effect
       Carboxymethyl polysaccharide in bio-protective film has strong antibacterial effect, and its antibacterial principle is
       First, the adsorption of polysaccharide molecules on the surface of the bacterial membrane changes the selective permeability of the cell membrane, resulting in loss of cytoplasm and separation of the cytoplasmic wall, thereby inhibiting bacteria and bactericidal action.
       Second, the polysaccharide molecules penetrate into the cells, adsorb the charged cytoplasm in the cells, flocculate, disrupt the normal physiological activities of the cells, or block the transcription of DNA in the cells to inhibit the proliferation of bacteria.
       Clinical comparison between bio-protective membrane and common antibacterial dressings